Double-pane insulated glass (IG) windows consist of two hermetically sealed panes of glass separated by an aluminum or stainless-steel spacer that contains silica beads that act as desiccants; they absorb moisture. The panes are sealed around this spacer with sealants like silicone or polyisobutylene. Some manufacturers use both to form primary and secondary seals that help extend the lifespan of the sealed unit.
Air in the space between the window panes expands when sun shines on the window, increasing air pressure between the panes. At night the window cools and air pressure between panes drops. If air pressure between the panes is higher or lower than the ambient air pressure (air pressure outside the panes) pressure will be created on the seals. During the day, high air pressure will try to push air out from between the panes and at night low pressure will try to pull air into this space. This is called "thermal cycling" or "thermal pumping".
Seals have to resist thermal cycling, UV radiation, moisture ingress, and must retain any inert gas (like argon) installed between the panes.
As windows age, the sealant that hermetically seals the space between panes ages, increasing amounts of air move into and out of the airspace between the panes. Water vapor entering this airspace is adsorbed by silica desiccant beads installed behind aluminum spacers installed around the perimeter of the glass assembly.
Eventually, this desiccant becomes saturated and can no longer adsorb moisture. Moisture vapor in the airspace then condenses on the interior of the panes.
Especially during initial failure, condensation may be visible only when the window is exposed to direct sunlight. Over time, this condensation will first stain- and then etch- the glass in a manner that is permanently visible.
Repair of Windows with Failed Seals
Companies exist that offer to repair failed seals by various means. I recommend that you not make a recommendation other than that the client contact a qualified contractor or window manufacturer to discuss options and costs for repair or replacement, although I typically mention that replacement is more common.
Windows may also be triple-pane, typically built using the same methods as double-pane or may be double-pane with a film down the center. In film-type windows, the film lifespan may be much shorter than the lifespan of other components.